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郑军平 副研究员

发布时间:2023-09-28 点击量:

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职称 副研究员

学位 博士

邮箱 junpingzheng13(at)hbucm.edu.cn (发邮件时请将(at)换成@)

主要招生专业及方向

中西医结合基础●生物技术在中医药研究中的应用

教育经历(从本科起倒序)

2013.09–2018.06,中国科学院大学(中国科学院大连化学物理研究所),硕博

2014.10–2018.03,中国科学院过程工程研究所,联合培养

2009.09–2013.06,南京林业大学,轻化工程(制浆造纸工艺),学士

主要工作经历(倒序)

2022.01–至 今, 湖北中医药大学基础医学院,副研究员

2018.07–2021.12,湖北中医药大学基础医学院,助理研究员

科研方向

1、药食质量控制相关的快速检测技术

2、中药调节糖脂代谢及肠道菌群的活性机制

学术兼职

1、中国中药协会中药质量与安全委员会第二届委员会委员

2、湖北省药理学会中药药理专业委员会第一届委员会委员

3、中国中西医结合学会第三届科研院所工作委员会青年委员

4、Journal of Advanced Research, Journal of Ethnopharmacology及Food Research International等杂志审稿人

5、湖北省“院士专家企业行”活动,对接湖北佳成生物科技有限公司

主要科研成果

主持项目(倒序)

1、湖北中医药大学杰出青年基金:等离子体凝胶传感体系研究与中药小分子现场检测应用,2023/06-2025/12,在研;

2、湖北省重点研发计划项目公益事业类:中药质量多维度一体化关键监测装置开发与应用(2023BCB098),2023/01-2025/12,在研;

3、湖北省中医药管理局指导性项目:黄精多糖“菌—肠—肾轴”防治慢性肾病的作用机制研究(ZY2023F129),2023/01-2024/12,在研;

4、湖北中医药大学ESI前1%学科建设专项B类(化学):2023/01-2023/12,在研;

5、武汉市科技局曙光计划项目:基于半胱氨酸催化氧化的简便显色体系构建及其疾病分子早诊技术应用(2022020801020422),2022/01-2023/12,在研;

6、湖北省教育厅重点项目:基于核酸识别放大的中药农残新型检测技术开发(D20222005),2022/01-2023/12,在研;

7、湖北省科技厅一般面上项目:基于胆汁酸-FXR/TGR5 信号通路的白及寡糖改善糖脂代谢紊乱的机制研究(2020CFB526),2020/03-2022/03,结题;

8、国家自然科学基金青年项目:从参苓白术散对宿主肠道菌群失衡及代谢产物表达的调节探讨健脾祛湿法抑制糖尿病发生的分子机(81903946),2020/01-2022/12,结题;

9、湖北省教育厅中青年人才项目:O-GlcNAc糖基化修饰在脂多糖诱导巨噬细胞炎症反应中的分子调节机制研究(Q20192004),2019/01-2020/12,结题;

10、湖北中医药大学博士科研启动资金:基于肠道菌群研究白芨寡糖调控糖脂代谢紊乱的作用机制,2019.9-2022.8,结题;

11、湖北中医药大学“青苗计划”:O-GlcNAc修饰调控NF-κB通路影响脂多糖所致炎症反应的分子机制研究(2019ZZX017),2019/01-2020/12,结题;

代表性论著(#共同第一作者,*通讯作者

1、Junping Zheng, Siming Jiao, Qiongyu Li, Peiyuan Jia, Heng Yin, Xiaoming Zhao, Yuguang Du*, Hongtao Liu*. Antrodia cinnamomea oligosaccharides suppress lipopolysaccharide-induced inflammation through promoting O-GlcNAcylation and repressing p38/Akt phosphorylation [J]. Molecules. 2018, 23(1): 51.

2、Junping Zheng, Gong Cheng, Qiongyu Li, Siming Jiao, Cui Feng, Xiaoming Zhao, Heng Yin, Yuguang Du*, Hongtao Liu*. Chitin oligosaccharide modulates gut microbiota and attenuates high-fat-diet-induced metabolic syndrome in mice [J]. Marine Drugs. 2018, 16(2): 66.

3、Junping Zheng, Xubing Yuan, Gong Cheng, Siming Jiao, Cui Feng, Xiaoming Zhao, Heng Yin, Yuguang Du*, Hongtao Liu*. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice [J]. Carbohydrate Polymers. 2018, 190: 77-86.

4、Junping Zheng#, Xubing Yuan#, Chen Zhang, Peiyuan Jia, Siming Jiao, Xiaoming Zhao, Heng Yin, Yuguang Du*, Hongtao Liu*. N-acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice [J]. Journal of Diabetes [J]. 2019, 11(1):32-45.

5、Junping Zheng, Lin Zhu, Baifei Hu, Xiaojuan Zou, Haiming Hu, Zhigang Zhang, Nan Jiang, Jun Ma, Huabing Yang*, Hongtao Liu*. 1-Deoxynojirimycin improves high fat diet-induced nonalcoholic steatohepatitis by restoring gut dysbiosis. Journal of Nutritional Biochemistry [J]. 2019, 71:16-26.

6、Junping Zheng#, Jing Zhang#, Yanlei Guo, Hairong Cui, Aizhen Lin, Baifei Hu, Qinghua Gao, Yunzhong Chen*, Hongtao Liu*. Improvement on metabolic syndrome in high fat diet-induced obese mice through modulation of gut microbiota by Sangguayin decoction. Journal of Ethnopharmacology [J]. 2020, 246: 112225.

7、Junping Zheng, Man Chen, Cheng Ye, Xiongjie Sun, Nan Jiang, Xiaojuan Zou, Huabing Yang*, Hongtao Liu*. BuZangTongLuo decoction improved hindlimb ischemia by activating angiogenesis and regulating gut microbiota in diabetic mice. Journal of Ethnopharmacology [J]. 2020, 248:112330.

8、Junping Zheng, Yanlei Guo, Baifei Hu, Lin Zhu, Yong Yang, Shengrong Li, Na Li, Hongtao Liu*. Serum metabolomic profiles reveal the impact of BuZangTongLuo formula on metabolic pathways in diabetic mice with hindlimb ischemia. Journal of Ethnopharmacology [J]. 2020, 258:112928.

9、Junping Zheng#, Cheng Ye#, Peng Wang, Yang Liu, Huabing Yang, Hongtao Liu*. Quantitative analysis of total methenolone in animal source food by liquid chromatography-tandem mass spectrometry. Drug Testing and Analysis [J]. 2021,13(1):148-155.

10、Junping Zheng#, Cheng Ye#, Baifei Hu, Huabing Yang, Qunfeng Yao, Jun Ma, Yang Liu, Hongtao Liu*. Bile acid profiles in bile and feces of obese mice by a high-performance liquid chromatography-tandem mass spectrometry. Biotechnology and Applied Biochemistry [J]. 2021, 68(6):1332-1341.

11、Junping Zheng, Yu Liu, Cheng Ye, Yang Liu, Zhigang Zhang, Mingzhu Yin, Qinghua Gao, and Hongtao Liu*. Durable Hydrogen Peroxide Biosensors Based on Polypyrrole-Decorated Platinum/Palladium Bimetallic Nanoparticles. ACS Applied Nano Materials[J]. 2021, 4 (8): 8116.

12、Baifei Hu, Cheng Ye, Elaine Lai-Han Leung, Lin Zhu, Haiming Hu, Zhigang Zhang, Junping Zheng*, Hongtao Liu*. Bletilla striata oligosaccharides improve metabolic syndrome through modulation of gut microbiota and intestinal metabolites in high fat diet-fed mice. Pharmacological Research [J]. 2020, 159:104942.

13、Jinhua Wang#, Junping Zheng#, Xianghui Ren, Shaojiang Wang, Guizhou Wang, Baifei Hu, Huabing Yang, Hongtao Liu*. Integrative analysis of hepatic metabolomic and transcriptomic data reveals potential mechanism of nonalcoholic steatohepatitis in high-fat diet-fed mice. Journal of Diabetes[J]. 2021, 13(5):390-401.

14、Yanan Cao, Cheng Ye, Cong Zhang, Guohao Zhang, Haiming Hu, Zhigang Zhang, Haitian Fang, Junping Zheng*, Hongtao Liu*. Simultaneous detection of multiple foodborne bacteria by loop-mediated isothermal amplification on a microfluidic chip through colorimetric and fluorescent assay[J]. Food Control. 2022, 134 :108694.

15、Yu Liu, Yanan Cao, Cong Zhang, Cheng Ye, Qinglai Bian, Xue Cheng, Hui Xia, Junping Zheng*, Hongtao Liu*. A novel colorimetric method for H2O2 sensing and its application: Fe2+-catalyzed H2O2 prevents aggregation of AuNPs by oxidizing cysteine (FeHOAuC). Analytica Chimica Acta[J]. 2022, 1207: 339840.

16、Ling Huang#, Junping Zheng#, Guangjun Sun, Huabing Yang, Xiongjie Sun, Xiaowei Yao, Aizhen Lin*, Hongtao Liu*. 5‐Aminosalicylic acid ameliorates dextran sulfate sodium‐induced colitis in mice by modulating gut microbiota and bile acid metabolism. Cellular and Molecular Life Sciences[J]. 2022, 79:460.

17、Cong Zhang, Ji Lv, Yanan Cao, Xiaowei Yao, Mingzhu Yin, Shuiqing Li, Junping Zheng*, Hongtao Liu*. A Triple-target Reverse Transcription Loop-mediated Isothermal Amplification (RT-LAMP) for Rapid and Accurate Detection of SARS-CoV-2 Virus. Analytica Chimica Acta[J]. 2023, 1255:341146.

18、Yu Liu, Fangfang Wang, Yawen Liu, Lu Cao, Haiming Hu, Xiaowei Yao, Junping Zheng*, Hongtao Liu*. A label-free plasmonic nanosensor driven by horseradish peroxidase-assisted tetramethylbenzidine redox catalysis for colorimetric sensing H2O2 and cholesterol. Sensors and Actuators: B. Chemical[J]. 2023, 389: 133893.

19、Yanan Li#, Junping Zheng#, Yao Wang, Huabing Yang, Lu Cao, Shuiyong Gan*, Jun Ma*, Hongtao Liu*. Immuno-stimulatory activity of Astragalus polysaccharides in cyclophosphamide-induced immunosuppressed mice by regulating gut microbiota. International Journal of Biological Macromolecules[J]. 2023, 124789.

20、Junping Zheng#, Jianghui Hu#, Yong Yang, Lei Xiong, Huabing Yang, Zhigang Zhang, Nan Jiang, Hongtao Liu. Suppressive effect of Tripterygium hypoglaucum (Levl.) Hutch extract on rheumatoid arthritis in mice by modulating inflammasome and bile acid metabolism. Biomedicine & Pharmacotherapy[J]. 2023. DOI: 10.1016/j.biopha.2023.115494.

21、黄意雯, 叶诚*, 郑军平*. O-GlcNAc 糖基化修饰调控炎症信号通路. 中国生物化学与分子生物学报,2021

22、郑军平, 刘洪涛, 杜昱光. O-乙酰氨基葡萄糖(O-GlcNAc)修饰及其生物学功能研究进展 [J]. 微生物学报. 2017, 57(8): 1141-1151.

23、郑军平, 原旭冰, 孟宪璞, 焦思明, 冯翠, 杜昱光, 刘洪涛. 壳寡糖抑制ApoE 基因敲除小鼠动脉粥样硬化的形成 [J]. 沈阳农业大学学报. 2018,49(2):150-157.

获奖及人才计划

1、2019年8月,被评为中国中西医结合学会诊断专业委员会第十三届全国学术研讨会的“大会特邀报告专家”。

2、2020年,获得Pharmacological Research 杂志社颁发的最佳中医药论文奖。

3、2021年,2020年度湖北省高层次人才计划,湖北中医药大学“杏林英才”拔尖人才。

4、2021年,获得校级“优秀学业导师”、“优秀共产党员”等称号

5、2023年,获校级“优秀党务工作者”称号,获批湖北中医药大学“杰出青年”基金。

发明专利(已授权)

1、杜昱光, 郑军平, 单俊伟, 王海华. 一种具有降血糖功能的浒苔低聚糖及其制备方法和应用 [P]. 申请号: 201711454376.X. (专利授权号:CN108003199B, 授权日:2020.08.18

2、刘洪涛, 郑军平, 杨化冰, 邹小娟, 孔明望, 张志刚, 夏慧, 陈会敏. 白芨寡糖及其组合物在调节糖脂代谢紊乱中的应用 [P]. 申请号: 201811270646.6. (申请日: 2018.10.29)(专利授权号:CN109364085B,授权日:2021.07.27

3、刘洪涛, 郑军平, 杨化冰, 邹小娟, 孔明望, 张志刚, 夏慧, 陈会敏. 白芨寡糖在改善肠道微生态中的应用 [P]. 申请号: 201811270639.6. (申请日:2018.10.29) (专利授权号:CN109010349B, 授权日:2020.11.06

4、刘洪涛, 朱琳, 郑军平, 杨化冰, 马骏, 孔明望, 姚小卫, 程雪. 壳寡糖在改善多种疾病所致的下肢缺血方面的应用 [P]. 申请号: 201910485251.6.(申请日: 2019.06.05)(专利授权号:CN110193022B, 授权日:2022.10.11

5、刘洪涛, 程雪, 郑军平, 杨化冰, 马骏, 邹小娟, 胡海明, 夏慧. 一种茯苓寡糖及其制备方法和应用 [P]. 申请号:201910417701.8. (申请日:2019.05.20) (专利授权号:CN109999046B,授权日:2021.06.04

6、刘洪涛, 朱琳, 郑军平, 孔明望, 马骏, 杨化冰, 孙雄杰, 胡海明. 茯苓寡糖的应用和用于治疗糖脂代谢疾病的药物组合物. [P]. 申请号:201910564718.6. (申请日:2019.06.27)(专利授权号:CN110123823B,授权日:2022.02.01

7、刘洪涛,叶诚,曹亚楠,郑军平,胡海明,杨化冰,张志刚,殷明珠. 一种利用LAMP技术快速检测伤寒沙门氏菌的引物组、检测方法、试剂盒[P]. 申请号: 202110070992.5(申请日:2021.01.20)(专利授权号:CN112725480B,授权日:2022.10.04

8、叶诚, 刘洪涛, 崔海荣, 郑军平, 詹承勇. 一种同时检测卤肉中瘦肉精和罂粟壳添加物的方法 [P]. 专利号: ZL201910325053.3 (授权日:2022.03.04)

主讲课程(研究生,本科)

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